Responsive image

Research: Topics

Researchers are listed below each major research area

Last update: 1 October 2012

“Wired” project

Boyden, Kopell, Wilson, Desimone, Eichenbaum, Graybiel, Miller, Eden, Kramer, Brown

  • Designing a system to collect and analyze electrical neural data from thousands of sites in the brain
  • High-throughput digital data storage and analysis architectures
  • Automated spike sorting methods
  • Geometries of probes

Optogenetic perturbation of brain rhythms

Boyden, Han, Kopell, Desimone, Brown, Borgers, Kramer, Ritt, Eden

  • Optogenetic perturbation of cognitive circuits
  • Technologies for automating neural recording
  • Protein delivery to neurons
  • Somatosensory cortex oscillations
  • Amygdala-hippocampal dynamics
  • Cortical dynamics and attention using optogenetics
  • Optogenetics and anesthesia effect analysis
  • Gamma oscillations and cell assemblies

Neural Data Analysis

Desimone, Kramer, Eden, Eichenbaum, Whittington, Ritt, Cheng, Sarma, Kopell, Purdon, Cash, Stufflbeam, Hamalainen, Vaina

  • Relationship between point processes and continuous signals
  • Disambiguating statistical covariates
  • Combining dynamical systems and statistical methods
  • Dynamical properties of optogenetic stimulation
  • Statistics of spiking in Parkinson’s Disease
  • Statistical changes in sleep and anesthesia
  • Data analysis and epilepsy
  • Analyzing connectivity from imaging data

Origins and propagation of rhythms

Moore, Jones, Kopell, Miller, Borgers, Boyden

  • Model and verification of MEG data
  • Gamma rhythms in the frontal cortex
  • Gamma rhythms and cell assemblies
  • Origins of the local field potential
  • Propagation of rhythms

Rhythms and cognition

Kopell, Jones, Moore, Whittington, Eichenbaum, Han, Miller, Wilson, Brown, Graybiel, Polley

  • Thalamic alpha Model
  • Alpha rhythms and attention
  • Beta rhythms and selective attention
  • Beta rhythms and the hippocampus
  • Causal evidence supporting a role for gamma and alpha oscillations in sensory information processing
  • Cholinergic modulation of attention
  • Multiple gamma rhythms in the auditory cortex and implications for bottom-up processing
  • Encoding rules using rhythms
  • Thalamic rhythms and cognition
  • Non-Traditional Mechanisms for Regulating Neocortical Dynamics: The Hemo-Neural Hypothesis

Dynamics of anesthesia and sleep

Brown, Kopell, Purdon, Wilson, Cash

  • Tracking coherence
  • Anteriorizarion
  • Burst suppression
  • Identifying general anesthesia
  • Mechanisms underlying ketamine anesthesia
  • Anesthetics and aging
  • Fibromyalgia and Sleep
  • Sleep Oscillations During REM
  • Ripple-Spindle Interactions during SWS

Parkinson’s Disease

Han, Boyden, Kopell, Eden, Cheng, Jones, Ritt

  • Dynamics in the basal ganglia loop
  • Deep Brain Stimulation


Kopell, Le Beau, Whittington, Kocsis

  • Aberrant interlaminar coupling
  • A Link between NMDA synapses and pathology of schizophrenia
  • Developmental models of schizophrenia
  • Other animal models of schizophrenia


Kramer, Cash, Moore, Eden, Jones, Stufflebeam, Hamalainen, Kopell, Borgers

  • Human brain voltage data during seizure
  • Non-invasive control of neural circuits
  • The “resting network”
  • A rodent model of epilepsy

Pediatric abnormalities

Jones, Hamalainen, Eden, Kramer